Figure 7.

Prediction of phosphorylation, O-GlcNAcylation and reciprocal sites for synapsin-1 and tau. (a) Predicted phosphorylation sites and (b) O-GlcNAcylation sites of synapsin-1. Prediction scores of phosphorylation and O-GlcNAcylation for Ser⁶⁰⁵ (marked by an arrow) were >0.5, and (c) the serine residue was identified as a potential reciprocal site (Ying–Yang score of 0.5). The horizontal line indicates the threshold (0.5) for modification potential, and the vertical lines show the potential phosphorylation and O-GlcNAcylation sites for the serine residue in the synapsin-1 peptide. (d) Predicted phosphorylation sites and (e) O-GlcNAcylation sites of tau. Prediction scores of phosphorylation and O-GlcNAcylation for Ser⁶⁹² (marked by an arrow) were greater than 0.7 and (f) the serine residue as identified as a potential reciprocal site (Ying–Yang score of 0.6).