Fig. 4.

Amino acid alignment of MDIR domain types I and II to various vertebrate IgSF domains. The position of the common amino acid motif KXWC is indicated by black shading. Conserved amino acids are indicated by asterisk. Amino acid sequences used in phylogenetic analyses are indicated by (+). Bold-face type indicates regions of β sheet structures as defined by X-ray crystallographic analysis. Arrows indicate likely intrachain disulfide bonds. Predicted structural characteristics (strands A through G) are indicated at the bottom