Figure 1.

Sequence Alignment of HsMCD, RpMCD, CmMCD, AvMCD, and ReMCD

The secondary structure elements for HsMCD are indicated at the top of the alignment, colored in yellow for those in the helical domain and cyan for those in the catalytic domain. Strictly conserved residues among the five sequences are shown in red and highly conserved residues in blue. The purple diamonds indicate sites of disease-causing missense mutations in HsMCD.