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Synthesis of the annulation precursor 17.
 | |||
| entry | oxidants | solvent | yield (%) |
| 1 | MnO2 | CH2Cl2 | no rxn (rt) |
| 2 | MnO2 | CH2Cl2 | decomp (40 °C) |
| 3 | BaMnO4 | CH2Cl2 | no rxn |
| 4 | DMP | CH2Cl2 | slow decomp |
| 5 | PCC | CH2Cl2 | decomp |
| 6 | TEMPO/oxone | toluene | no rxn |
| 7 | TPAP/NMO | CH2Cl2 | decomp |
| 8 | Pyr-SO3/DMSO | CH2Cl2 | 85% |
