Table 2.
Biological activities of Egyptian herbal medicines against different bioassays related to AD
|
No. |
Plant species |
Screening data |
IC50(μg/ml) |
||||
|---|---|---|---|---|---|---|---|
| % inhibition of ACHEa | % inhibition of COX-1b | DPPH (%AA)b | ACHE | COX-1 | DPPH | ||
| 1 |
A.vasica |
86.0 |
- |
19.0 |
294 |
N.D |
>100 |
| 2 |
A. vera. |
- |
- |
31.0 |
- |
N.D |
>100 |
| 3 |
A. pyrethrum L. |
21.0 |
- |
90.0 |
N.D |
N.D |
26.3 |
| 4 |
B. sacra |
−46.0 |
15.1 ± 5.7 |
8.0 |
N.D |
N.D |
>100 |
| 5 |
B. alba |
16.0 |
52.3 ± 2.1 |
24.0 |
N.D |
N.D |
>100 |
| 6 |
B. nigra. |
19.0 |
10.9 ± 1.6 |
42.0 |
N.D |
N.D |
>100 |
| 7 |
E. officinalis |
- |
- |
97.0 |
N.D |
N.D |
6.3 |
| 8 |
F. assafoetida |
3.0 |
96.7 ± 1.3 |
17.0 |
N.D |
3.2 |
>100 |
| 9 |
M. officinalis |
−49.0 |
- |
6.0 |
N.D |
N.D |
>100 |
| 10 |
C. fistula. |
−16.0 |
19.2 ± 4.8 |
66.0 |
N.D |
N.D |
75.0 |
| 11 |
N. oleander. |
- |
- |
60.0 |
N.D |
N.D |
64.5 |
| 12 |
N. sativa. |
5.0 |
55.4 ± 8.8 |
19.0 |
N.D |
N.D |
>100 |
| 13 |
P. harmala. |
92.0 |
- |
41.0 |
68 |
N.D |
>100 |
| 14 |
P. nigrum. |
34.0 |
- |
30.0 |
N.D |
N.D |
>100 |
| 15 |
R. palmatum. |
−20.0 |
- |
95.0 |
N.D |
N.D |
14.2 |
| 16 |
R. officinalis. |
10.0 |
11 ± 5.4 |
82.0 |
N.D |
N.D |
19.4 |
| 17 |
R. graveolens. |
8.0 |
- |
69.0 |
N.D |
N.D |
61.0 |
| 18 |
S. triloba. |
- |
- |
93.0 |
N.D |
N.D |
20.7 |
| 19 |
S. aromaticum |
47.0 |
80.3 ± 0.9 |
89.0 |
N.D |
34.9 |
15.9 |
| 20 |
T. arjuna |
−10.0 |
- |
96.0 |
N.D |
N.D |
3.1 |
| 21 |
T. chebula |
13.0 |
- |
95.0 |
N.D |
N.D |
2.2 |
| 22 |
T. polium |
16.0 |
- |
51.0 |
N.D |
N.D |
96.4 |
| 23 |
Z. officinalis |
−45.0 |
68.2 ± 3.1 |
47.0 |
N.D |
33.6 |
>100 |
| |
Galanthamine |
n/a |
n/a |
n/a |
9.4 |
n/a |
n/a |
| |
Indomethancin |
n/a |
n/a |
n/a |
n/a |
0.61 |
n/a |
| |
Reference DPPH scavengers: |
|
|
|
|
|
|
| t-BHQ |
|
|
|
|
|
2.8 |
|
| Gallic acid |
|
|
|
|
|
1.2 |
|
| Quercetin | 4.5 | ||||||
aat 1000 μg/ml, bat 100 μg/ml, N.D not detected, n/a not applicable.