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. 2013 Jul 4;8(7):e67693. doi: 10.1371/journal.pone.0067693

Figure 2. Lcn-2 KO mice are increasingly susceptible to NTS.

Figure 2

WT (black bar; n = 13) and Lcn-2 KO mice (white bar; n = 12) were subjected to NTS. (A) Albuminuria was evaluated on day 0 and day 7 after NTS induction. (B) On day 7 after NTS induction kidney sections were evaluated for PAS positive deposits. (C) The percentage of crescentic glomeruli was quantified in WT and Lcn-2 KO mice. Data are given as means ± SEM. *p<0.05. (D) Representative PAS-stained sections of WT and Lcn-2 KO mice are shown. PAS positive glomeruli are marked by open arrows. A small crescent formation is marked by an asterix. Tubular cells with PAS positive material inserted because of heavy proteinuria are marked by closed arrows. Magnification x400.