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. 2013 Jul 4;8(7):e67693. doi: 10.1371/journal.pone.0067693

Figure 6. Lcn-2 expressed in circulating immune cells protects mice from NTS.

Figure 6

WT (black bar; n = 10), Lcn-2 KO (white bar; n = 8) and chimeras (WT→KO, dark grey bar, n = 6; KO→WT, light grey bar, n = 8) were subjected to NTS. (A) On day 14 after induction of NTS albuminuria was evaluated. (B) Representative PAS-stained kidney sections are shown. Magnfication x400. (C) Tubular necrosis was assessed in WT→KO and KO→WT chimeras by H&E staining. (D) WT mice and KO→WT chimeras were analyzed for their urinary Lcn-2 concentration 0, 7 and 14 days after NTS induction. (E) On day 14 the serum Lcn-2 concentration of the two groups was evaluated. Data are given as mean ± SEM. *p<0.05, **p<0.01.