Table 5.
Overrepresented functional annotations describing genes that show non-uniform variance as a function of sleep duration
| Annotation cluster 1 | Enrichment score: 14.904263431729085 | |||
|---|---|---|---|---|
|
Category |
Term |
P Value |
Fold Enrichment |
FDR |
| SP_PIR_KEYWORDS |
Microsome |
4.15E-24 |
23.74 |
5.37E-21 |
| KEGG_PATHWAY |
Retinol metabolism |
3.03E-20 |
17.72 |
3.19E-17 |
| SP_PIR_KEYWORDS |
Heme |
3.00E-19 |
15.99 |
3.89E-16 |
| SP_PIR_KEYWORDS |
Monooxygenase |
5.41E-19 |
19.11 |
7.00E-16 |
| SP_PIR_KEYWORDS |
Oxidoreductase |
1.09E-18 |
6.50 |
1.41E-15 |
| KEGG_PATHWAY |
Drug metabolism |
6.69E-18 |
15.30 |
7.05E-15 |
| GOTERM_BP_FAT |
GO:0055114 ~ oxidation reduction |
3.07E-16 |
5.27 |
5.22E-13 |
| SP_PIR_KEYWORDS |
Iron |
6.73E-15 |
8.04 |
8.76E-12 |
| KEGG_PATHWAY |
Metabolism of xenobiotics by cytochrome P450 |
7.52E-15 |
14.78 |
7.96E-12 |
| KEGG_PATHWAY |
Linoleic acid metabolism |
3.42E-13 |
17.46 |
3.61E-10 |
| SP_PIR_KEYWORDS |
endoplasmic reticulum |
4.12E-13 |
4.87 |
5.33E-10 |
| KEGG_PATHWAY |
Arachidonic acid metabolism |
1.33E-07 |
8.30 |
1.40E-04 |
| SP_PIR_KEYWORDS |
metal-binding |
4.05E-04 |
1.69 |
5.22E-01 |
|
Annotation Cluster 2 |
Enrichment Score: 7.639984508416769 |
|
|
|
|
Category |
Term |
P Value |
Fold Enrichment |
FDR |
| KEGG_PATHWAY |
Complement and coagulation cascades |
3.36E-15 |
13.77 |
3.52E-12 |
| GOTERM_BP_FAT |
GO:0009611 ~ response to wounding |
2.76E-10 |
5.96 |
4.32E-07 |
| GOTERM_BP_FAT |
GO:0007596 ~ blood coagulation |
3.19E-08 |
14.07 |
4.99E-05 |
| GOTERM_BP_FAT |
GO:0050817 ~ coagulation |
3.19E-08 |
14.07 |
4.99E-05 |
| GOTERM_BP_FAT |
GO:0007599 ~ hemostasis |
3.63E-08 |
13.87 |
5.67E-05 |
| GOTERM_BP_FAT |
GO:0050878 ~ regulation of body fluid levels |
2.66E-07 |
11.06 |
4.15E-04 |
| SP_PIR_KEYWORDS |
blood coagulation |
1.33E-06 |
19.52 |
1.72E-03 |
| GOTERM_BP_FAT |
GO:0042060 ~ wound healing |
1.89E-06 |
8.79 |
2.95E-03 |
| SP_PIR_KEYWORDS |
Plasma |
7.60E-05 |
21.50 |
9.83E-02 |
|
Annotation Cluster 3 |
Enrichment Score: 5.173741168245643 |
|
|
|
|
Category |
Term |
P Value |
Fold Enrichment |
FDR |
| KEGG_PATHWAY |
Steroid hormone biosynthesis |
2.85E-09 |
14.03 |
3.01E-06 |
| KEGG_PATHWAY |
Drug metabolism |
5.61E-09 |
13.15 |
5.92E-06 |
| KEGG_PATHWAY |
Androgen and estrogen metabolism |
1.09E-06 |
13.91 |
1.15E-03 |
| KEGG_PATHWAY |
Ascorbate and aldarate metabolism |
3.62E-06 |
22.95 |
3.82E-03 |
| KEGG_PATHWAY |
Pentose and glucuronate interconversions |
1.67E-04 |
16.88 |
1.76E-01 |
| KEGG_PATHWAY |
mmu00500:Starch and sucrose metabolism |
3.41E-04 |
9.56 |
3.59E-01 |
| SP_PIR_KEYWORDS | Glycosyltransferase | 7.02E-04 | 4.67 | 9.04E-01 |
Annotation clusters were provided by DAVID. Only annotations with an FDR <5% are retained and only the top 3 clusters are shown.