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. 2013 Jul 4;8(7):e67911. doi: 10.1371/journal.pone.0067911

Figure 4. [18F]FLT-PET indicates response of i.c. growing gliomas to TMZ after 2 days of treatment.

Figure 4

Representative [18F]FLT-PET images at days 0 and 2 and corresponding T2w-MR images at day -1 and day 6 of two mice bearing an orthotopic i.c. Gli36dEGFR-1 xenograft and receiving daily injection of DMSO (A) or 25 mg/kg TMZ (B). [18F]FLT accumulation was reduced in Gli36dEGFR-1 xenografts in response to treatment with TMZ. C. Quantitative analysis of changes in [18F]FLT T/B uptake ratio after 2 days (as determined by PET) and in size after 6 days (as determined by T2w-MRI) of daily injection of DMSO (ntumor = 4) and 25 mg/kg TMZ (ntumor = 5) for the Gli36dEGFR-1 i.c. xenografts. Differences between the treated and control groups were tested for significance using T-Test or Mann-Whitney Rank Sum Test (*: P<0.05; **: P<0.01). D. A positive correlation (Spearman rank correlation analysis) was observed between changes in [18F]FLT T/B uptake ratio between day 0 and day 2 and changes in size between day -1 and day 6.