Table 1. Spurious association rates in the exome data.

	PC1
PC2	OR 1/5 Fourth	OR 1/5 Half	OR 1/5 Full	OR 1	OR 5 Full	OR 5 Half	OR 5 Fourth
OR 1/5 Fourth	0.0686	0.0548	0.0448	0.0400	0.0421	0.0501	0.0660
OR 1/5 Half	0.0683	0.0543	0.0442	0.0402	0.0425	0.0521	0.0680
OR 1/5 Full	0.0686	0.0544	0.0441	0.0397	0.0443	0.0524	0.0684
OR 1	0.0700	0.0555	0.0442	0.0389	0.0434	0.0527	0.0707
OR 5 Full	0.687	0.0522	0.0434	0.0391	0.0454	0.0541	0.0684
OR 5 Half	0.0683	0.0530	0.0441	0.0395	0.0444	0.0530	0.0689
OR 5 Fourth	0.0641	0.0494	0.0401	0.0393	0.0448	0.0539	0.0667

The values are the average spurious association rate for ten run using 1,000 cases and controls from the European Americans in the Exome Sequencing Project. These are the rates at the 5% significance threshold for parameters defined as odds ratios (ORs) of 1/5, 1, or 5 for a fourth, half, or full distance between the minimum and maximum for each axis: PC1 are the columns, and PC2 are the probabilities calculated for each individual. Smaller values indicate larger differences in disease risk among individuals in PC space.