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SOCS3 expression in antigen-presenting cells prevented IL-6-mediated inhibition of IL-12 secretion SOCS3 expression in T cells reduces the frequency of γδ+ T cells in different organs and the secretion of IL-17 by γδ+ T cells in response to infection in a gp130-independent manner. Expression of Socs3 in myeloid and lymphoid cell populations is critical for a proper control of M. tuberculosis infection.
