Table 1. Gene set enrichment analysis of ANRIL trans-regulated genes in cell lines ANRIL1-4.

Function	ANRIL1	ANRIL2	ANRIL3	ANRIL4
Cellular Development	1.43×10−04	7.02×10−12	3.43×10−04	2.52×10−09
Cellular Movement/Adhesion	4.53×10−03	4.21×10−06	2.18×10−04	1.67×10−07
Cellular Growth and Proliferation	1.71×10−05	5.24×10−09	4.90× 10−06	9.91×10−07
Cell Death/Apoptosis	6.27×10−04	8.29×10−08	2.38×10−05	4.54×10−06
Cell-To-Cell Signaling and Interaction	3.49×10−03	3.00×10−04	2.14×10−04	1.52×10−05
Cellular Assembly and Organization	1.21×10−03	5.77×10−04	9.71×10−04	3.63×10−05
Cellular Function and Maintenance	1.21×10−03	4.78×10−04	7.29×10−04	7.21×10−05
Gene Expression	1.21×10−03	1.83×10−03	2.95×10−04	1.32×10−04
Cell Morphology	5.01×10−03	6.65×10−04	5.99×10−04	7.46×10−04

Genes with expression changes of <0.5 and >2 in ANRIL over-expressing cell lines 1–4 compared to vector control were included in the analysis: ANRIL1- n = 893 (<0.5 n = 439/>2 n = 454 compared to control), ANRIL2- n = 2658 (<0.5 n = 1116/>2 n = 1542 compared to control), ANRIL 3- n = 1830 (<0.5 n = 1054/>2 n = 776 compared to control), and ANRIL4- n = 2982 (<0.5 n = 1514/>2 n = 1468 compared to control). P-values for enrichment of trans-regulated genes (www.ingenuity.com) are given.