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. Author manuscript; available in PMC: 2013 Jul 4.
Published in final edited form as: Expert Rev Anticancer Ther. 2011 Aug;11(8):1283–1294. doi: 10.1586/era.11.111

Table 2.

Role of Bcl-2 family members on apoptosis and autophagy.

Bcl-2 family member HUGO gene symbol Effect on apoptosis Effect on autophagy
Bcl-2 BCL2 Antiapoptotic Inhibits autophagy by binding to beclin-1
Bcl-w BCL2L2 Antiapoptotic Inhibits autophagy by binding to beclin-1
Bcl-XL BCL2L1 Antiapoptotic Inhibits autophagy by binding to beclin-1
Mcl-1 MCL1 Antiapoptotic Inhibits autophagy (to a lesser extent than Bcl-2, Bcl-w and Bcl-XL) by binding to beclin-1
Bad BAD Proapoptotic Promotes autophagy by competitively binding to Bcl-2, Bcl-w and Bcl-XL
t-Bid BID Proapoptotic Promotes autophagy by competitively binding to Bcl-2, Bcl-w and Bcl-XL
BimEL BCL2L11 Proapoptotic Promotes autophagy by competitively binding to Bcl-2, Bcl-w and Bcl-XL
Noxa PMAIP1 Proapoptotic Promotes autophagy by competitively binding to Bcl-2, Bcl-w and Bcl-XL
Puma BBC3 Proapoptotic Promotes autophagy by competitively binding to Bcl-2, Bcl-w and Bcl-XL
BNIP3L BNIP3L Proapoptotic Promotes autophagy by competitively binding to Bcl-2, Bcl-w and Bcl-XL
Bik BIK Proapoptotic Promotes autophagy by competitively binding to Bcl-2, Bcl-w and Bcl-XL
Bax BAX Proapoptotic No effect
Bak BAK1 Proapoptotic No effect

HUGO: Human Genome Organisation.