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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Cancer Prev Res (Phila). 2013 May 16;6(7):675–685. doi: 10.1158/1940-6207.CAPR-13-0064

Figure 2. Effect of naproxen or NO-naproxen on UV-induced skin tumorigenesis.

Figure 2

Groups of 20 female SKH-1 mice were placed on their experimental diets and exposed to UV irradiation thrice weekly. Tumors were counted weekly and the data calculated as the average number of tumors per mouse (panel A). Tumor multiplicity for 100 ppm naproxen was significantly (p= 0.05) different from the UV control group; 400 ppm naproxen and NO-naproxen were very significantly (p<0.001) different from the UV control. Tumor incidence (panel B) was calculated as the percentage of mice bearing tumors. Mice in the 400 ppm naproxen, 100 ppm and 400 ppm NO-naproxen groups developed tumors significantly (p<0.001 for all 3 groups) slower than the UV control.