Fig. 3.

Treatment with the cell cycle inhibitor CR8 attenuates the effects of contusion SCI on neuronal activity in posterior nucleus. Group data show a significant effect of treatment on both spontaneous (a, p = 0.0004) and sensory-evoked activity (b, p = 0.0001). (a) One-way analysis of variance with Bonferonni correction revealed that spontaneous firing rates in spinal cord injury (SCI) animals with vehicle treatment (n = 33 cells) were significantly higher than those in SCI animals treated with CR8 (p = 0.017, n = 35 cells) and sham animals (vehicle, p = 0.008, n = 24; CR8, p < 0.001, n = 30). However, activity in SCI animals receiving CR8 was not significantly different from either sham group. (b) Similarly, evoked firing rates were significantly higher in SCI vehicle animals than those in SCI CR8 animals (p = 0.001) and sham (vehicle, p = 0.001; CR8, p = 0.002). There was no difference between firing rates from SCI CR8 and either sham treatment condition