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. 2013 Jul 5;4:166. doi: 10.3389/fphys.2013.00166

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Copyright © 2013 Adeniran, Hancox and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Changes in steady state SR content induced by conditioning trains of action potentials of differing duration. (A) Protocol used to determine steady state SR content, comprised of train of 100 normal (black) and shortened (red) AP clamp commands followed by a 300 ms square command voltage pulse to +10 mV. (B) I_CaL elicited by the +10 mV voltage command. Peak I_CaL is equal with the two AP waveforms in (A). (C) Normalized [Ca²⁺]_i elicited by the by the +10 mV voltage command. Values are normalized to maximum [Ca²⁺]_i for the “normal” AP waveform. (D) Normalized active force elicited by the +10 mV voltage command. Values are normalized to maximum active force for the normal AP waveform. (E) Normalized maximum SR Ca²⁺ content prior to the application of +10 mV voltage command in (A). Values are normalized to maximum SR Ca²⁺ for the normal AP waveform.