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. 2013 Jul 5;4:166. doi: 10.3389/fphys.2013.00166

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Copyright © 2013 Adeniran, Hancox and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Effects of I_sac on the WT, SQT1, and SQT3 electromechanics model. (Ai–Ci) WT (black), SQT1 (blue) and SQT3 (green) action potentials in the EPI (Ai), MCELL (Bi), and ENDO (Ci) cell models. (Aii–Cii) WT (black), SQT1 (blue) and SQT3 (green) intracellular calcium concentration and Ca²⁺ transients in the EPI (Aii), MCELL (Bii), and ENDO (Cii) cell models. (Aiii–Ciii) WT (black), SQT1 (blue) and SQT3 (green) sarcomere length (SL) in the EPI (Aiii), MCELL (Biii), and ENDO (Ciii) cell models. (Aiv–Civ) WT (black), SQT1 (blue) and SQT3 (green). SAC in these simulations were permeable to Na⁺, K⁺, and Ca²⁺ in the ratio 1:1:1.