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. Author manuscript; available in PMC: 2014 Jul 2.
Published in final edited form as: Structure. 2013 Jul 2;21(7):1085–1096. doi: 10.1016/j.str.2013.05.009

Figure 6. Hinge structural conformations in the prefusion and post-fusion conformation of Influenza HA.

Figure 6

Prefusion) The pH sensitive hinge (cyan) is depicted in the prefusion state interacting with HA1. A salt bridge between Glu69 of HA2 and Arg120 of HA1 is shown that stabilizes the heterodimer interface (1JSD) Hinge Post-Fusion) The hinge adopts an α-helical configuration where an AniAni interaction is formed between Glu69 and Glu74 on the adjacent chain (1HTM).