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. 2013 Jul 5;3:2142. doi: 10.1038/srep02142

Figure 2. Identification of small-molecule compounds that correct aberrant splicing of Clcn1.

Figure 2

(a) A luciferase reporter assay showed that manumycin A corrected aberrant splicing in the presence of the expanded CUG repeat (mean + SEM, n = 3). (b) Cellular splicing analysis showed that manumycin A corrects aberrant splicing of Clcn1. (c) Quantification of the results shown in (b) (mean + SEM, n = 3). (d) Structure of manumycin A. The gel image was cropped around the region of interest and the samples (n = 3) were resolved in the same gel. Statistical significance was determined using t-tests (*p < 0.05, **p < 0.01).