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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: J Med Chem. 2013 May 9;56(10):3749–3767. doi: 10.1021/jm400422s

Figure 1 .

Figure 1

A. The time-dependent progressive activation (white arrows) of receptors for nucleosides and nucleotides on the cell surface. The 4 subtypes of ARs and 8 subtypes of P2YRs are arranged in a dendrogram according to their sequence homology. Although the ligands have commonality, the ARs and 8 subtypes of P2YRs are on distant branches of the larger dendrogram of Family A GPCRs. B. General characteristics of adenosine as a GPCR ligand and its receptors as therapeutic targets in both chemical (A) and biological (B) contexts.