Table II.
Subgroup analysis
| Characteristic | All-cause mortality | Combination of all-cause mortality and non-fatal MI | ||||||
|---|---|---|---|---|---|---|---|---|
| Data points, No. | Pooled RR (95% CI) | Value of p for heterogeneity | Value of p for subgroup difference | Data points, No. | Pooled RR (95% CI) | Value of p for heterogeneity | Value of p for subgroup difference | |
| All studies | 7 | 1.90 (1.45-2.50) | 0.11 | 7 | 1.75 (1.36-2.26) | 0.051 | ||
| Follow-up term [years] | ||||||||
| < 3 | 5 | 1.62 (0.93-2.81) | 0.05 | 0.81 | 4 | 1.85 (1.39-2.47) | 0.22 | 0.31 |
| ≥ 3 | 4 | 1.85 (1.34-2.53) | 0.28 | 3 | 1.67 (0.96-2.91) | 0.04 | ||
| Type of CHD | ||||||||
| Stable CHD | 3 | 1.85 (1.34-2.53) | 0.28 | 0.81 | 2 | 1.99 (0.91-4.36) | 0.11 | 0.79 |
| ACS | 4 | 1.62 (0.93-2.81) | 0.05 | 5 | 1.80 (1.26-2.57) | 0.06 | ||
| Assay for PAPP-A | ||||||||
| ELISA or POC assay | 6 | 5 | 1.83 (1.43-2.36) | 0.25 | 0.18 | |||
| Other | 1 | 2 | 1.54 (0.74-3.20) | 0.03 | ||||
ACS – acute coronary syndrome, CHD – coronary heart disease, ELISA – enzyme-linked immunosorbent assay, MI – myocardial infarction, PAPP-A – pregnancy-associated plasma protein A, POC assay – point-of-care time-resolved immunofluorometric assay