. 2013 May 10;121(7):832–838. doi: 10.1289/ehp.1205797

Table 3.

Associations between urinary arsenic metabolite indices and CVD risk.

Urinary arsenic metabolicindex	Mean^a	Subcohort (n)	CVD		Heart disease		Stroke
Urinary arsenic metabolicindex	Mean^a	Subcohort (n)	Cases (n)	aHR (95%CI)^b	Cases (n)	aHR (95%CI)^b	Cases (n)	aHR (95%CI)^b
iAs%^c
0.3–12.4	9.3	363	157	1.00	92	1.00	63	1.00
12.5–17.3	14.8	367	118	1.28 (0.90, 1.81)	60	1.12 (0.74, 1.68)	53	1.39 (0.84, 2.29)
17.4–69.3	23.2	363	91	1.05 (0.71, 1.56)	56	1.17 (0.76, 1.80)	32	0.87 (0.49, 1.57)
MMA%^c
0.2–10.3	7.7	366	74	1.00	40	1.00	32	1.00
10.4–14.3	12.3	363	131	1.27 (0.85, 1.90)	81	1.65 (1.05, 2.60)	49	0.91 (0.51, 1.61)
14.4–33.8	18.6	364	161	1.55 (1.08, 2.23)	87	1.61 (1.04, 2.49)	67	1.35 (0.81, 2.27)
DMA%^c
27.9–68.6	61.6	363	117	1.00	74	1.00	39	1.00
68.7–75.5	72.1	367	133	0.98 (0.69, 1.39)	65	0.65 (0.43, 0.98)	64	1.53 (0.91, 2.55)
75.6–99.2	80.2	363	116	0.75 (0.49, 1.14)	69	0.68 (0.44, 1.05)	45	0.90 (0.48, 1.67)
PMI^c
0.01–0.66	0.48	362	83	1.00	48	1.00	34	1.00
0.67–1.05	0.85	365	98	0.93 (0.65, 1.34)	56	0.91 (0.59, 1.39)	37	0.88 (0.52, 1.51)
1.06–19.57	1.61	363	185	0.88 (0.61, 1.26)	104	0.91 (0.59, 1.40)	77	0.81 (0.49, 1.34)
SMI^c
1.4–4.8	3.6	361	152	1.00	88	1.00	59	1.00
4.9–7.1	5.9	363	136	1.00 (0.72, 1.38)	77	1.02 (0.70, 1.48)	56	1.00 (0.61, 1.64)
7.2–32.3	10.5	363	77	0.54 (0.34, 0.85)	43	0.54 (0.33, 0.88)	32	0.58 (0.31, 1.08)
Abbreviations: PMI, primary methylation index; SMI, secondary methylation index.^aCategory-specific mean values of urinary arsenic metabolites in the subcohort. ^bAdjusted for sex, baseline age (years), BMI, smoking status (never and ever), educational attainment, hypertension, and diabetes status. ^cCut points were determined by tertiles in the subcohort.