. 2013 May 10;121(7):797–803. doi: 10.1289/ehp.1206003

Table 3.

Multivariable regression analyses^a of the influence of N6AMT1 genotypes on fractions of arsenic metabolites.

Metabolite/SNP	Genotype^b	n	Mean (95%CI)^c	Model 1		Model 2
Metabolite/SNP	Genotype^b	n	Mean (95%CI)^c	β (95%CI)	p-Value	β (95%CI)	p-Value
iAs
rs1997605	AA	63	13.1 (11.6, 14.6)
	AG	75	12.5 (11.1, 13.9)	–0.60 (–2.7, 1.5)	0.57	–0.69 (–2.7, 1.3)	0.50
	GG	50	12.6 (10.9, 14.3)	–0.50 (–2.8, 1.7)	0.66	–1.1 (–3.3, 1.1)	0.33
rs2205449	AA	30	13.8 (11.7, 16.0)
	TA	81	12.5 (11.2, 13.8)	–1.3 (–3.9, 1.2)	0.30	–1.2 (–3.7, 1.3)	0.34
	TT	77	12.5 (11.1, 13.9)	–1.3 (–3.9, 1.2)	0.30	–1.7 (–4.2, 0.79)	0.18
rs2705671	TT	71	12.8 (11.4, 14.2)
	GT	70	13.1 (11.6, 14.5)	0.27 (–1.8, 2.3)	0.80	–0.047 (–2.0, 1.9)	0.96
	GG	43	12.0 (10.2, 13.9)	–0.76 (–3.1, 1.6)	0.52	–1.3 (–3.5, 1.0)	0.28
rs16983411	AA	181	12.8 (11.9, 13.7)
	AG	4	10.1 (4.1, 16.0)	–2.7 (–8.7, 3.3)	0.38	–3.5 (–9.4, 2.4)	0.24
rs1048546	GG	60	13.2 (11.7, 14.8)
	GT	77	12.5 (11.0, 13.8)	–0.80 (–2.9, 1.3)	0.45	–0.91 (–2.9, 1.1)	0.38
	TT	50	12.6 (10.9, 14.3)	–0.63 (–2.9, 1.6)	0.59	–1.4 (–3.6, 0.88)	0.23
MMA
rs1997605	AA	63	7.7 (7.0, 8.6)
	AG	75	8.6 (7.8, 9.2)	0.67 (–0.44, 1.8)	0.23	0.53 (–0.51, 1.6)	0.32
	GG	50	9.6 (8.9, 10.7)	1.9 (0.74, 3.1)	0.0017	1.5 (0.35, 2.6)	0.011
rs2205449	AA	30	7.2 (6.0, 8.3)
	TA	81	8.6 (7.8, 9.2)	1.3 (–0.070, 2.7)	0.063	1.3 (0.058, 2.6)	0.041
	TT	77	9.2 (8.6, 10.0)	2.1 (0.75, 3.5)	0.0026	1.8 (0.55, 3.1)	0.0054
rs2705671	TT	71	7.7 (7.0, 8.5)
	GT	70	8.7 (7.9, 9.4)	0.84 (–0.24, 1.9)	0.12	0.65 (–0.38, 1.7)	0.21
	GG	43	9.6 (8.8, 10.7)	2.0 (0.73, 3.2)	0.0020	1.6 (0.41, 2.8)	0.0087
rs16983411	AA	181	8.5 (8.0, 9.0)
	AG	4	11.6 (8.6, 15.0)	3.3 (0.063, 6.6)	0.046	2.7 (–0.41, 5.7)	0.089
rs1048546	GG	60	7.5 (6.7, 8.4)
	GT	77	8.8 (7.9, 9.4)	1.1 (0.011, 2.2)	0.048	0.97 (–0.72, 2.0)	0.068
	TT	50	9.7 (8.9, 10.7)	2.3 (1.1, 3.5)	0.00024	1.8 (0.61, 2.9)	0.0031
DMA
rs1997605	AA	63	79.2 (77.3, 80.9)
	AG	75	78.9 (77.4, 80.7)	–0.068 (–2.6, 2.4)	0.96	0.16 (–2.2, 2.5)	0.89
	GG	50	77.8 (75.6, 79.7)	–1.5 (–4.2, 1.3)	0.29	–0.41 (–3.0, 2.2)	0.75
rs2205449	AA	30	79.0 (76.4, 81.6)
	TA	81	79.0 (77.5, 80.7)	0.032 (–3.0, 3.1)	0.98	–0.14 (–3.0, 2.8)	0.92
	TT	77	78.3 (76.6, 79.8)	–0.81 (–3.9, 2.3)	0.60	–0.16 (–3.1, 2.8)	0.92
rs2705671	TT	71	79.5 (77.7, 81.2)
	GT	70	78.4 (76.6, 80.1)	–1.1 (–3.6, 1.4)	0.38	–0.60 (–2.9, 1.7)	0.61
	GG	43	78.2 (76.0, 80.5)	–1.2 (–4.0, 1.6)	0.40	–0.33 (–3.0, 2.3)	0.80
rs16983411	AA	181	78.8 (77.7, 79.8)
	AG	4	78.3 (70.9, 85.3)	–0.64 (–7.9, 6.7)	0.86	0.82 (–6.0, 7.7)	0.81
rs1048546	GG	60	79.4 (77.4, 81.1)
	GT	77	78.8 (77.3, 80.6)	–0.31 (–2.8, 2.2)	0.81	–0.058 (–2.4, 2.3)	0.96
	TT	50	77.8 (75.6, 79.6)	–1.7 (–4.4, 1.1)	0.23	–0.40 (–3.0, 2.2)	0.76
^aModel 1: Arsenic metabolite = α+β×genotype+γ×U-As (ln transformed). Model 2: Arsenic metabolite =α+β× genotype+γ×U-As (ln)+λ×AS3MT haplotype. ^bAllele genotypes associated with lower %MMA are denoted first. ^cMean values and 95% CIs are adjusted values based on model1.