. 2013 May 10;121(7):797–803. doi: 10.1289/ehp.1206003

Table 5.

Multivariable regression analyses^a of haplotype × haplotype interaction between AS3MT (haplotype 2) and N6AMT1 (haplotype 1) and fractions of arsenic metabolites.

Metabolite	AS3MT haplotype2+N6AMT1 haplotype1^b	n	Mean (95%CI)^c	β (95%CI)	p-Value
iAs
	2 copies AS3MT+2 copies N6AMT1	15	12.1 (9.1, 15.1)
	2 copies AS3MT+1 copy N6AMT1	44	11.7 (9.9, 13.5)	–0.42 (–3.9, 3.1)	0.82
	2 copies AS3MT+0 copies N6AMT1	31	10.6 (8.5, 12.7)	–1.5 (–5.1, 2.2)	0.43
	1 copy AS3MT+2 copies N6AMT1	12	13.7 (10.4, 17.1)	1.6 (–2.9, 6.1)	0.48
	1 copy AS3MT+1 copy N6AMT1	30	13.7 (11.6, 15.9)	1.6 (–2.1, 5.3)	0.38
	1 copy AS3MT+0 copies N6AMT1	33	13.2 (11.1, 15.2)	1.0 (–2.6, 4.7)	0.57
	0 copies AS3MT+1 and 2 copies N6AMT1	8	15.6 (11.5, 19.8)	3.5 (–1.6, 8.7)	0.18
	0 copies AS3MT+0 copies N6AMT1	13	15.1 (11.9, 18.4)	3.0 (–1.4, 7.4)	0.18
MMA
	2 copies AS3MT+2 copies N6AMT1	15	6.2 (4.6, 7.8)
	2 copies AS3MT+1 copy N6AMT1	44	7.2 (6.3, 8.1)	1.0 (–0.75, 2.8)	0.27
	2 copies AS3MT+0 copies N6AMT1	31	8.2 (7.1, 9.3)	2.0 (0.17, 3.9)	0.038
	1 copy AS3MT+2 copies N6AMT1	12	8.0 (6.2, 9.7)	1.8 (–0.55, 4.1)	0.13
	1 copy AS3MT+1 copy N6AMT1	30	9.5 (8.4, 10.6)	3.3 (1.3, 5.1)	0.001
	1 copy AS3MT+0 copies N6AMT1	33	9.7 (8.7, 10.8)	3.5 (1.7, 5.5)	0.00029
	0 copies AS3MT+1 and 2 copies N6AMT1	8	11.1 (9.0, 13.2)	4.9 (2.0, 7.3)	0.00032
	0 copies AS3MT+0 copies N6AMT1	13	10.4 (8.7, 12.0)	4.2 (1.9, 6.5)	0.00041
DMA
	2 copies AS3MT+2 copies N6AMT1	15	81.8 (78.3, 85.3)
	2 copies AS3MT+1 copy N6AMT1	44	81.1 (79.1, 83.2)	–0.65 (–4.7, 3.4)	0.75
	2 copies AS3MT+0 copies N6AMT1	31	81.1 (78.7, 83.6)	–0.67 (–4.9, 3.6)	0.76
	1 copy AS3MT+2 copies N6AMT1	12	78.3 (74.4, 82.2)	–3.5 (–8.7, 1.8)	0.20
	1 copy AS3MT+1 copy N6AMT1	30	76.8 (74.3, 79.2)	–4.9 (–9.2, –0.57)	0.027
	1 copy AS3MT+0 copies N6AMT1	33	77.1 (74.8, 79.5)	–4.7 (–8.9, –0.47)	0.030
	0 copies AS3MT+1 and 2 copies N6AMT1	8	73.3 (68.5, 78.1)	–8.3 (–14, –2.3)	0.007
	0 copies AS3MT+0 copies N6AMT1	13	74.6 (70.8, 78.3)	–7.2 (–12, –2.1)	0.006
^aModel: Arsenic metabolite (%iAs or %DMA or %MMA)=α+β×AS3MT haplotype/N6AMT1 haplotype+γ×U-As (ln transformed). ^bAS3MT+N6AMT1 haplotypes associated with lower %MMA are denoted first. ^cMean values and 95% CIs are adjusted values based on the presented statistical model.