Table 2.
Mean BMR20TCDD concentrations for TCDD, PeCDD, 4-PeCDF, PCB-126, PCB-118, and PCB-156 and corresponding REPs for various end points in liver and PBLs.
| Tissue/biomarker | Dose metric | TCDD | PeCDD | 4-PeCDF | PCB-126 | PCB-118 | PCB-156 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMR20TCDD | REP | BMR20TCDD | REP | BMR20TCDD | REP | BMR20TCDD | REP | BMR20TCDD | REP | BMR20TCDD | REP | ||
| LiverEROD activity | Adm dose (µg/kg BW) | 0.29 | 1 | 0.54 | 0.5 | 4.11 | 0.07 | 29.3 | 0.01 | 55,259 | 0.000005 | 15,664 | 0.00002 |
| Syst liver (ng/g liver) | 1.61 | 1 | 4.85 | 0.3 | 32.9 | 0.05 | 373 | 0.004 | 25,441 | 0.00006 | 7,501 | 0.0002 | |
| Syst liver (ng/g lipid) | 34.6 | 1 | 99.6 | 0.3 | 913 | 0.04 | 9,938 | 0.003 | 720,241 | 0.00006 | 217,711 | 0.0002 | |
| Syst adipose (ng/g lipid) | 1.23 | 1 | 1.25 | 1 | 3.47 | 0.4 | 72.7 | 0.02 | 359,114 | 0.000003 | 82,483 | 0.00001 | |
| Syst plasma (ng/g lipid) | 1.38 | 1 | 2.31 | 0.6 | 3.50 | 0.4 | 72.3 | 0.02 | 311,118 | 0.000004 | 98,188 | 0.00001 | |
| LiverCyp1a1 mRNA | Adm dose (µg/kg BW) | 0.64 | 1 | 1.25 | 0.5 | 81.3 | 0.008 | 558 | 0.001 | 139,631 | 0.000005 | 44,305 | 0.00001 |
| Syst liver (ng/g liver) | 4.35 | 1 | 12.0 | 0.4 | 725 | 0.006 | 4,299 | 0.001 | 62,418 | 0.00007 | 35,669 | 0.0001 | |
| Syst liver (ng/g lipid) | 77.5 | 1 | 216 | 0.4 | 13,768 | 0.006 | 70,368 | 0.001 | 1,693,882 | 0.00005 | 634,215 | 0.0001 | |
| Syst adipose (ng/g lipid) | 2.50 | 1 | 2.36 | 1 | 59.8 | 0.04 | 315 | 0.008 | ND | 180,515 | 0.00001 | ||
| Syst plasma (ng/g lipid) | 2.66 | 1 | 3.94 | 0.7 | 37.6 | 0.07 | 0.32 | 0.008 | 803,766 | 0.000003 | 303,586 | 0.000009 | |
| LiverCyp1b1 mRNA | Adm dose (µg/kg BW) | 3.55 | 1 | 10.1 | 0.4 | 150 | 0.02 | ND | ND | 95,664 | 0.00004 | ||
| Syst liver (ng/g liver) | 29.1 | 1 | 105 | 0.3 | 1,577 | 0.02 | ND | ND | 72445.7 | 0.0004 | |||
| Syst liver (ng/g lipid) | 391 | 1 | 1,655 | 0.2 | 32,921 | 0.01 | ND | ND | 1,158,251 | 0.0003 | |||
| Syst adipose (ng/g lipid) | 10.3 | 1 | 19.4 | 0.5 | 461 | 0.02 | ND | ND | 745,126 | 0.00001 | |||
| Syst plasma (ng/g lipid) | 11.6 | 1 | 18.5 | 0.6 | 44.6 | 0.3 | ND | ND | 553,459 | 0.00002 | |||
| LiverCyp1a2 mRNA | Adm dose (µg/kg BW) | 0.41 | 1 | 0.56 | 0.7 | 8.83 | 0.05 | 87.4 | 0.005 | 15,522 | 0.00003 | 12,085 | 0.00003 |
| Syst liver (ng/g liver) | 2.59 | 1 | 4.59 | 0.6 | 68.1 | 0.04 | 912 | 0.003 | 8,833 | 0.0003 | 4,239 | 0.0006 | |
| Syst liver (ng/g lipid) | 51.1 | 1 | 95.3 | 0.5 | 1,712 | 0.03 | 21,240 | 0.002 | 267,405 | 0.0002 | 166,060 | 0.0003 | |
| Syst adipose (ng/g lipid) | 1.73 | 1 | 1.20 | 1 | 6.53 | 0.3 | 120 | 0.01 | 117,517 | 0.00001 | 22,134 | 0.00008 | |
| Syst plasma (ng/g lipid) | 1.85 | 1 | 2.36 | 0.8 | 8.01 | 0.2 | 135 | 0.01 | 103,230 | 0.00002 | 60,702 | 0.00003 | |
| PBLsCyp1a1 mRNA | Adm dose (µg/kg BW) | 22.4 | 1 | 33.7 | 0.7 | 117 | 0.2 | 603 | 0.04 | ND | 747,734 | 0.00003 | |
| Syst plasma (ng/g lipid) | 50.6 | 1 | 34.0 | 1.5 | 40.8 | 1 | 847 | 0.06 | ND | 2,359,081 | 0.00002 | ||
| PBLsCyp1b1 mRNA | Adm dose (µg/kg BW) | 20.9 | 1 | 51.8 | 0.4 | 514 | 0.04 | ND | ND | ND | |||
| Syst plasma (ng/g lipid) | 53.5 | 1 | 63.8 | 0.8 | 212 | 0.3 | ND | ND | ND | ||||
| PBLsCyp1a2 mRNA | Adm dose (µg/kg BW) | ND | ND | ND | ND | ND | ND | ||||||
| Syst plasma (ng/g lipid) | ND | ND | ND | ND | ND | ND | |||||||
| Abbreviations: Adm, administered; ND, not determined because BMR20TCDD was not reached; Syst, systemic. Data are expressed as mean BMR20TCDD derived from dose–response curves of 6 mice. REPs were calculated as described in “Materials and Methods.“ | |||||||||||||