Table 1.
Inciting molecules in animal studies and intraocular cytokine profiles in patients with ME
| Inciting molecules in animal studies | |
| Prostaglandins | Cytokines |
| PGE1 | VEGF-A |
| PGE2 | P1GF |
| PGF2a | TNF-α |
| Leukotrienes | IL-1β |
| LTB4 | IGF-1 |
| LTC4 | IL-6 |
| LTD4 | SDF-1 |
| Nitric oxide | HGF |
| PAF | CA |
| PKC-β | |
| Intraocular cytokine profiles with ME | |
| Increases in: | Decreases in: |
| VEGF-A | TGF-β |
| FGF2 | sVEGFR-1 |
| Erythropoietin | |
| IL-6 | |
| IFN-Γ | |
| HGF | |
| PGE2 | |
| CA | |
P1GF = Placental growth factor; IGF-1 = insulin-like growth factor-1; PKC-ß = protein kinase C-ß; TGF-ß = transforming growth factor-ß; sVEGFR-1 = soluble VEGF receptor-1.