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. Author manuscript; available in PMC: 2014 Jun 12.
Published in final edited form as: J Am Chem Soc. 2013 Jun 3;135(23):8472–8475. doi: 10.1021/ja4032488

Figure 3.

Figure 3

DNA-catalyzed hydrolysis of all-RNA substrates. (A) 10MD5 reselection, seeking hydrolysis at the original cleavage site within the binding arm. (B) Entirely new N40 selection, seeking hydrolysis at the unpaired nucleotides.