. Author manuscript; available in PMC: 2013 Jul 5.

Published in final edited form as: Curr Opin Immunol. 2008 Oct 14;20(6):697–702. doi: 10.1016/j.coi.2008.09.004

Table I.

IL-17 cytokine family and functional effects on allergy

Ligands	Receptors	Functions	References
IL-17A	IL-17RA	IL-6, IL-8, IL-11, Gro-α, G-CSF and GM-CSF ↑	[38]
IL-17F	IL-17RA/C	MUC5AC and MUC5B ↑	[34]
		Airway hyper-reactivity ↑	[16]
		Neutrophilia ↑	[33]
		Severity of asthma ↑	[16]
IL-17E	IL-17RB	IL-4, IL-5, IL-13, IgE, and eotaxin ↑	[40,42,43,44,45,46,50]
		Mucus secretion ↑	[44,45]
		Airway hyper-reactivity ↑	[40,47,50]
		Eosinophilia ↑	[40,42,44,50]
		Severity of asthma ↑	[40,44,47,50]