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. Author manuscript; available in PMC: 2013 Jul 5.
Published in final edited form as: J Huntingtons Dis. 2012 Nov 27;1(2):221–241. doi: 10.3233/JHD-129005

Fig. 8.

Fig. 8

Mutant HTT staining in FVB.CAG140 and YAC128 mice. Representative images of mutant HTT labeled with EM48 in the non-injected striatum. Little staining is present in1 month-old FVB.CAG140 (A) HET, but (B, C) HOM knock-in mice have light nuclear staining (arrowhead). Four month-old, (D) HET and (E, F) HOM FVB.CAG140 mice have increased nuclear staining (arrowheads) with aggregation in the HOM compared to HET mice. By 12 months of age, nuclear staining and nuclear inclusions (arrows) are apparent in both (G) HET and (H, I) HOM FVB.CAG140 mice. (J, K) Staining performed in parallel of sections from 12 month old YAC128 mice have considerably less mutant HTT staining than 4 month-old HET and HOM FVB.CAG140 mice (D–F). Nuclear staining (arrowheads) and aggregation (arrows) is denoted, although this is less intense than FVB.CAG140 knock-in mice. (L) Sections from WT FVB/N has no EM48 staining. Scale bar = 100 μm (50 μm in C, F, I, K).