Table 1.
Group numbers and attrition
| Age (mo.) | Strain | Genotype | No. mice injected | No. mice euthanized | Deaths due to: |
|---|---|---|---|---|---|
| Experiment: QUIN, 7 day survival
| |||||
| 1 | FVB | WT | 12 | 11 | |
| 1 | FVB | HET | 13 | 12 | Anesthesia |
| 1 | FVB | HOM | 13 | 10 | Surgery, anesthesia |
| 2 | FVB | WT | 10 | 10 | |
| 2 | FVB | HET | 14 | 12 | Recovery |
| 2 | FVB | HOM | 10 | 10 | |
| 4 | FVB | WT | 10 | 10 | |
| 4 | FVB | HET | 10 | 10 | |
| 4 | FVB | HOM | 8 | 8 | |
| 12 | FVB | WT | 8 | 6 | Anesthesia, recovery |
| 12 | FVB | HET | 8 | 6 | Anesthesia, recovery |
| 12 | FVB | HOM | 7 | 6 | Recovery |
| 1 | C57BL/6 | WT | 11 | 10 | Anesthesia |
| 1 | C57BL/6 | HET | 11 | 9 | Anesthesia, recovery |
| 1 | C57BL/6 | HOM | 11 | 11 | |
| 2 | C57BL/6 | WT | 12 | 9 | Anesthesia, recovery |
| 2 | C57BL/6 | HET | 13 | 10 | Anesthesia, recovery |
| 2 | C57BL/6 | HOM | 12 | 9 | Anesthesia, recovery |
| 4 | C57BL/6 | WT | 11 | 9 | Anesthesia |
| 4 | C57BL/6 | HET | 12 | 10 | Anesthesia, recovery |
| 4 | C57BL/6 | HOM | 9 | 7 | Anesthesia |
| 12 | C57BL/6 | WT | 11 | 8 | Anesthesia, recovery |
| 12 | C57BL/6 | HET | 8 | 7 | Recovery |
| 12 | C57BL/6 | HOM | 9 | 4 | Anesthesia, recovery |
|
| |||||
| Experiment: QUIN time course, 10, 13 or 16 day survival
| |||||
| 6 or 12 | FVB | WT | 13 | 12 | Recovery |
| 12 | FVB | HET | 13 | 12 | Recovery |
|
| |||||
| Experiment: QUIN, 7 day survival, comparing HD mouse models
| |||||
| 12 | FVB | WT | 15 | 10 | Anesthesia, recovery |
| 12 | FVB | YAC128 | 14 | 14 | |
| 12 | FVB | HET | 3 | 3 | |
| 12 | FVB | HOM | 1 | 1 | |
|
| |||||
| Experiment: Kainic acid treatment, 3 day survival
| |||||
| 12 | FVB | WT | 2 | 2 | |
| 12 | FVB | HET | 10 | 7 | Within 3 hrs post KA |
| 12 | FVB | HOM | 5 | 1 | Within 3 hrs post KA |