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. 2013 May 21;21(7):1306–1315. doi: 10.1038/mt.2013.86

Figure 2.

Figure 2

Serum antibody titers to human HexA in AAV-treated cats. Sandhoff disease (SD) or normal cats treated by intracranial injection of AAV vectors expressing human Hex were assayed at experimental or humane endpoint for serum antibodies to human HexA. AAV-treated SD cats had significantly lower titers compared with AAV-treated normal cats (*P = 0.011 with the inclusion of 7-589, or P = 0.009 with omission of 7-589, which was pre-treated by intravenous injection before intracranial injection). Average titers of at least two assays are shown. AAV, adeno-associated virus.