Table 3.
No. prior Aza courses | Best response Aza | Reason off Aza/Weeks off Aza | Weeks from prior Aza before DAC | Best response DAC/Courses to response | Response Duration (months) | Percent marrow Blasts Pre/at response | Platelets Pre/at response | ANC Pre/at response | |
---|---|---|---|---|---|---|---|---|---|
1 | 8 | Marrow CR | PD | 3 | CR/3 | 9.7 | 15/1 | 24/336 | 1.1/3.2 |
2 | 4 | SD | NR | 11 | Marrow CR/3 | 8.2 | 8/4 | 65/95 | 1.8/5.1 |
3 | 4 | SD | NR | 9 | CR/5 | 11.3+ | 12/3 | 80/234 | 0.6-1.4 |
4 | 1 | N/A | Toxicity | 5 | CR/1 | 10.2 | 13/4 | 24/110 | 0.38/2.8 |
Abbreviations: CR= complete remission, Aza= azacitidine, DAC= decitabine, SD=stable disease, PD= progressive disease, NR= no response, ANC= absolute neutrophil count