Table 2b.
Odds ratio of CAC≥75th percentile per SD increment of HDL-C measure or HDL-C genetic risk score in the Framingham Heart Study Offspring cohort
| Model | OR (95% CI) | P-value |
|---|---|---|
| HDL cholesterol (Exam 1) | ||
| Age + sex | 0.84 (0.74–0.95) | 0.007 |
| Age + sex + HDL-C genetic risk score | 0.85 (0.75–0.97) | 0.01 |
| HDL cholesterol (Exam 7) | ||
| Age + sex + lipid treatment (Exam 7) | 0.91 (0.80–1.03) | 0.13 |
| Age + sex + lipid treatment (Exam 7) + HDL-C genetic risk score | 0.92 (0.80–1.05) | 0.19 |
| HDL cholesterol (average, Exams 1–7) | ||
| Age + sex + lipid treatment (any) | 0.84 (0.74–0.95) | 0.007 |
| Age + sex + lipid treatment (any) + HDL-C genetic risk score | 0.84 (0.74–0.96) | 0.01 |
| HDL-C genetic risk score | ||
| Age + sex | 1.06 (0.94–1.20) | 0.34 |
| Age + sex + HDL-C (Exam 1) | 1.05 (0.92–1.19) | 0.51 |
| Age + sex + HDL-C (Exam 7) + lipid treatment (Exam 7) | 1.04 (0.91–1.19) | 0.54 |
| Age + sex + HDL-C (average, Exams 1–7) + lipid treatment (any) | 1.01 (0.88–1.15) | 0.92 |