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The effects of the CB1 receptor antagonist AM251 on PKA RIα and PKCδ expression in the ARC. Bars represent means and vertical lines 1 SEM of the mRNA expression determined in ARC tissue harvested after seven days of treatment with AM251 (3 mg/kg; s.c.) or its cremephor/ethanol/0.9% saline vehicle (0.1 ml; s.c.). *, Values measured in AM251-treated animals that are significantly different (Mann-Whitney W test; p < .05; n = 4 – 9) than those measured in vehicle-treated controls.
