Figure 2.

CPEB1 reduces senescence by regulating p53 distribution in glioma cells. (a) A cell growth assay was used to analyze the function of CPEB1 siRNA in glioma cell proliferation. *P<0.05. (b) The effect of CPEB1 siRNA on senescence in glioma cell lines as determined with SA-β-gal staining. Arrows indicate the green senescent cells. *P<0.05. (c) Transmission electron micrographs of the morphology of glioma cells transfected with CPEB1 siRNA. (d) The regulation of p53 and p21 by CPEB1 siRNA. (e) The changes in the cellular distribution of p53 induced by CPEB1 siRNA in the U87 cell line