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. 2013 Jun 27;69(Pt 7):723–729. doi: 10.1107/S1744309113015182

Figure 2.

Figure 2

Consensus geometry of central turns in TOG-domain HEAT-like repeats. (a) A representative HEAT-like repeat of the conserved turn geometry. Shown is the backbone and secondary structure of Mast-M1 residues 125–159 (turn D; TD) renumbered to reflect a position within a canonical HEAT-like repeat. Ribbon residues colored red (canonical residues 11–23) served as a target for substructure searching using distance geometry matching (Finzel et al., 2011 ▶). (b) 14 matching substructures from known TOG-domain structures including Mast-M1 TB, TC, TD and TE, Stu2p TA, TD and TE, Msps TA, TD and TE and Zyg9 TA, TC, TD and TE. Some repeats exhibit very different geometry outside of the turn (shown as a Cα trace). (c) The sequence logo (Schneider & Stephens, 1990 ▶) arising from alignment of these 14 similar substructures.