Table 3.
Two year uncensored graft loss Cox regression analysis
| |
Univariable |
Multivariable model 1 |
Multivariable model 2 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Delayed graft function |
3.58 |
1.93 to 6.65 |
< 0.001 |
3.12 |
1.65 to 5.87 |
< 0.001 |
3.23 |
1.82 to 6.09 |
< 0.001 |
| IL-2 minus |
2.63 |
1.45 to 4.78 |
0.001 |
2.28 |
1.22 to 4.30 |
0.01 |
2.02 |
1.04 to 3.93 |
0.04 |
| Time on dialysis (per year) |
1.28 |
1.05 to 1.57 |
0.02 |
1.27 |
1.01 to 1.60 |
0.04 |
1.27 |
1.01 to 1.61 |
ns |
| Recipient age (per year) |
1.03 |
1.00 to 1.06 |
0.03 |
1.02 |
0.99 to 1.05 |
ns |
1.02 |
0.99 to 1.05 |
ns |
| Any HLA-A mismatch |
0.61 |
0.32 to 1.16 |
0.1 |
0.74 |
0.38 to 1.44 |
ns |
0.68 |
0.35 to 1.34 |
ns |
| Tacrolimus versus CsA |
0.34 |
0.08 to 1.41 |
0.1 |
0.44 |
0.10 to 1.98 |
ns |
0.46 |
0.10 to 2.11 |
ns |
| Recipient gender (male) |
1.70 |
0.82 to 3.54 |
0.2 |
1.41 |
0.66 to 2.99 |
ns |
1.36 |
0.64 to 2.90 |
ns |
| Donor gender (male) |
0.72 |
0.40 to 1.30 |
0.3 |
0.80 |
0.43 to 1.49 |
ns |
0.80 |
0.43 to 1.50 |
ns |
| Steroid-resistant rejection | 2.17 | 1.01 to 4.67 | 0.05 | - | - | - | 1.80 | 0.78 to 4.15 | ns |
N = 232; 42 graft loss, no missing variables.
The following variables were tested in the univariable model but not included in the multivariable model: CMV-positive donor, CMV-positive recipient, presence of HLA antibodies, donor age, any HLA-B or HLA-DR mismatch, cold ischemia time and presence of acute rejection episode 90 or 180 days after transplantation.