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Edmundson wheel projection of (A) Holothuroidin 1 and (B) Holothuroidin 2 calculated by the Helical Wheel Projection web tool. Residues are schematically represented by geometric figures. Hydrophilic residues = circles, hydrophobic residues = diamonds, potentially negatively charged = triangles, and potentially positively charged = pentagons. In the centre mean relative hydrophobic moment and hydrophobic arc (@) are indicated.
