Effect of a 3-mo CAT treatment (n = 6) on cerebral artery myogenic tone induced by an intraluminal pressure of 60 mmHg in cerebral arteries isolated from 3- and 6-mo-old WT (n = 8 and 6, respectively) and ATX (n = 6) mice, before and after acute addition of L-NNA (10 μmol/l). Data are means ± SE of n mice. One-way ANOVA: P < 0.05 vs. 3-mo-old WT (*), vs. 3-mo-old ATX (†), vs. 6-mo-old WT (‡), and vs. 6-mo-old ATX (§). Paired t-test: aP < 0.05 vs. control condition in the absence of L-NNA.