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. 2013 Jul 5;8(7):e68498. doi: 10.1371/journal.pone.0068498

Figure 5. Effect of increasing intraluminal pressure in cannulated cerebral arterial segments on the activity levels of the phosphatase PTEN and the kinase Akt.

Figure 5

Pressurization of the cannulated cerebral arterial segments at 120 mm Hg for 60 minutes exhibited a significant oxidative inactivation of PTEN, whereas this increase in intraluminal pressure induced elevated level of phosphorylated Akt as revealed by the change in density of the expression level of the protein bands for PTEN and phospho-Akt. Bar graphs depict summary of the density of the protein bands presented as mean ± SEM for the oxidized and reduced forms of PTEN and for that of phospho-Akt. n = 2–3 trials per group. *P<0.01, # P<0.05 compared to control group.