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. 2013 Jul 5;8(7):e68498. doi: 10.1371/journal.pone.0068498

Figure 6. Pharmacological inhibition of endogenous PTEN activity enhances elevation in intraluminal pressure induced myogenic cerebral arterial constriction.

Figure 6

Pretreatment of cannulated and pressurized cerebral arterial segments with the phosphatase PTEN inhibitor bpV(phen) (at concentrations of 3,10 or 30 µM) (A) or bpV(pic) (at concentrations of 3,10 or 30 µM) (B) for 30 min over intraluminal pressure range of 20 to 120 mm Hg in 20 mm Hg steps caused concentration-dependent enhancement of the increase in intraluminal pressure-induced myogenic constriction. n = 4–5 independent experiments. *and † denote significant difference at P<0.05. The PTEN inhibitor bpV(phen) induced potentiation of the myogenic response that reached maximum starting at 10 µM, whereas the PTEN inhibitor bpV(pic) appeared to elicit enhamcement of the pressure-dependent myogenic tone at 30 µM.