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. Author manuscript; available in PMC: 2014 Jul 2.
Published in final edited form as: Structure. 2013 Jun 6;21(7):1137–1148. doi: 10.1016/j.str.2013.04.025

Figure 2.

Figure 2

Crystal structure of mouse TBK1. (A). Domain organization of mTBK1, showing the boundaries of the kinase domain (KD), ubiquitin-like domain (ULD), the scaffold and dimerization domain (SDD), and the TANK-binding domain (TBD). The construct used for crystallization is truncated at the C-terminus of the SDD at residue Thr657. (B). Ribbon representation of the structure of the mTBK1 monomer colored rainbow from blue at the N-terminus to red at the C-terminus. The inhibitor SU6668 is shown by the yellow stick model. (C). Close up of the interface between the KD (blue) and the SDD (red). Residues mediating the interactions between the two domains are shown by the stick models. (D). Interactions between the KD (blue) and the ULD (green). (E). Close up of the interface between the ULD (green) and the SDD (red).