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Mouse TBK1 exhibits distinct domain organization compared to the canonical IκB kinase. (A). Superposition of mTBK1 (blue, green, and red) and Xenopus IKKβ (yellow) structures via the kinase domains. (B). Structure of the mTBK1 dimer viewed along the SDD helical bundles (red and brown). The C-termini of the SDDs point away from the reader. (C). Structure of Xenopus IKKβ in the same orientation as mTBK1, showing the different arrangement of its KD and ULD relative to the SDD.
