TABLE 1.

Patient Characteristics of IA Cytoreductive Chemotherapy and Conventional Treatment for Adenoid Cystic Carcinoma of the Lacrimal Gland

Patient No.	Age/Gender/Affected Side	ACC Subtype/Perineural/Bone Infiltration	IACC Cycles/Total Cycles	Prior Tumor Resection	Radiographic Tumor Response/Tissue Margins	Treatment	Time (mo) of and Status at Last Follow-Up	Time (mo) of Local Recurrence/Met	Remarks
Group 1
1	29/M/OD	Basa/P/B	3/4	NO	Yes/−	Exent + RT	288; Alive, no D	No	Intracranial extension
3	73/F/OS	Basa/P	2/6	NO	Yes/−	Exent + RT	193; Alive, no D	No	Kidney transplant
4	58/M/OS	Crib/P	2/6	NO	Yes/−	Exent + RT + GK	156; Alive, no D	No	Intracranial, ethmoid sinus ACC
5	35/M/OS	Crib/P	3/6	NO	Yes/+	Exent + RT	149; Alive, no D	No	Non-healing apex; free flap
7	30/M/OS	Basa/P	2/4	NO	Yes/−	Exent + Bone + RT	116; Alive, no D	No
10	29/F/OD	Basa	2/6	NO	Yes/−	Exent + RT	96; Alive, no D	No
17	53/F/OD	Basa	2/6	NO	Yes/−	Exent + RT	29; Alive, no D	No	Neck dissection negative
18	44/M/OS	Basa/Crib/P/B	3/6	NO	Yes/+	Exent + RT	20; Alive, no D	No	Lung Bx negative
Group 2
2	32/M/OD	Crib/P/B	3/6	YES	Yes/−	Exent + Bone + RT	167; Died, no D	No	HIV. Died of oral SCC
6	42/F/OD	Crib/P/B	3/6	YES	Yes/−	Exent + Bone + RT	127; Alive, with D	50; Lung	Bone necrosis, hearing deficit; 7th N palsy
8	36/F/OS	Basa/P/B	2/2	NO	Yes/+	Exent + RT	28; Died of D	18; LR/Liver	Delayed exent, refused final 4 cycles
9	64/F/OD	Crib/B	2/2	YES	Yes/+	Exent orbit/sinuses + Bone + RT	112; Alive, no D	13; LR/Sinus	Delayed exent, refused final 4 cycles, ACC in sinus mucosa resected
11	54/M/OS	Crib/Basa	2/6	YES	Yes/+	Exent + Bone + TM +RT	87; Died of D	20; LR/Lung/Brain	Extensive disease at presentation
12	32/F/OD	Crib	2/5	YES	Yes/+	Exent + Bone + RT + GK	85; Alive, no D	No
13	34/M/OD	Crib	2/6	YES	Yes/−	Exent + Bone + RT	89; Alive, no D	No	Ophthal artery infusion, vessel thrombosis
14	49/M/OS	Crib/Basa	2/5	YES	Yes/−	Exent + Bone + RT	82; Alive, no D	60; Lung	NED after lung nodule resection
15	20/M/OD	Crib/Basa/P/B	3/5	YES	Yes/−	Exent + Bone + RT	73; Alive; no D	No
16	38/F/OS	Basa	2/6	YES	Yes/+	Exent + RT	52; Alive; no D	No
19	56M/OS	Basa/P	5/5	YES	Yes/+	Exent orbit/sinuses + RT	20; Alive; no D	No	Intracranial and ethmoid sinus ACC, free flap
Alternate Histology
20	43/F/OS	Adenocar/P/B	2/6	YES	Yes/−	Exent + RT	41; Died; no D	No	No ACC detected in exenteration specimen; AML 3 years post IACC; 11q23 translocation + margin at superior orbital fissure
21	45/F/OD	Adenocar/P/B	2/2	NO	Yes/+	Exent + RT	30; Died of D	26; Brain
Conventional Treatment Group
1	37/M/OS	Basa	N/A	N/A		Exent + RT	22; Died of D	3; LR/Sinus
2	57/F/OD	Crib/P/B	N/A	N/A		Resect + RT	94; Died of D	36; LR/Lung
3	48/M/OD	Basa	N/A	N/A		Resect + Exent	157; Died of D	No
4	42/F/OD	Basa	N/A	N/A		Resect	18; Died of D	7; Brain
5	69/M/OS	Basa	N/A	N/A		Exent + RT	198; Died of D	84; Brain
6	53/F/OS	Crib	N/A	N/A		Exent + RT	8; Died of D	5; Brain
7	37/M/OD	Crib/P/B	N/A	N/A		Exent + Bone + RT	44; Died of D	16; Lung

ACC = adenoid cystic carcinoma; Basa = basaloid subtype; Crib = cribriform subtype; B = bone infiltration; P = perineural infiltration; Radiographic Tumor Response/Tissue Margins = radiographic evidence of tumor shrinkage after IA chemotherapy cycles/presence of tumor cells at soft tissue surgical margins; No D = No ACC; LR = local recurrence; Met = distant metastases; D = disease (local or metastatic ACC); Exent + bone + RT = exenteration with removal of lateral orbital wall fragment plus postoperative radiation therapy; TM = temporalis muscle resection; Exent + RT = exenteration plus postoperative radiation therapy; GK = gamma knife therapy; NED = no evidence of disease; N/A = not applicable; Resect = primary resection of mass; SCC = squamous cell carcinoma; 7^th N = facial nerve palsy; Adenocar = adenocarcinoma; AML = acute myelocytic leukemia.