Table 1.
Characteristics of participants by statin use, MESA, 2000–2002
| Statin Use (n=1001) | No statin use (n=5786) | P | |
|---|---|---|---|
| Age, mean years (SD) | 65.9 (8.7) | 61.5 (10.3) | < 0.001 |
| Male, n (%) | 468 (46.7) | 2727 (47.1) | 0.82 |
| Race/ethnicity, n (%) | <0.001 | ||
| Caucasian | 431 (43.1) | 2177 (37.6) | |
| African American | 289 (28.9) | 1598 (27.6) | |
| Hispanic | 178 (17.8) | 1311 (22.7) | |
| Chinese | 103 (10.3) | 700 (12.1) | |
| Education, n (%) | 0.38 | ||
| High school or less | 167 (16.7) | 1051 (18.2) | |
| Some College | 484 (48.4) | 2674 (46.7) | |
| Bachelor’s degree or higher | 349 (34.9) | 2040 (35.4) | |
| Income, n (%) (272 missing income data) | 0.64 | ||
| ≤ $20,000 | 240 (25.0) | 1312 (23.6) | |
| $20,000–49,000 | 347 (36.1) | 2033 (36.6) | |
| ≥ $50,000 | 373 (38.8) | 2210 (40) | |
| Hormone replacement use, n (%) | 157 (15.7) | 870 (15.0) | 0.87 |
| Diabetes, n (%) | 222 (22.2) | 631 (10.9) | <0.001 |
| Hypertension, n (%) | 636 (63.5) | 2406 (41.6) | <0.001 |
| Current smoker, n (%) | 98 (9.8) | 789 (13.6) | 0.001 |
| Alcohol, current use, n (%) | 555 (55.7) | 3179 (55.4) | 0.84 |
| BMI, mean kg m2 (SD) | 28.9 (5.2) | 28.2 (5.5) | <0.001 |
| LDL cholesterol, mean mg/dl (SD) | 104 (28) | 120 (31) | <0.001 |
| HDL cholesterol, mean mg/dl (SD) | 50 (14) | 51 (15) | 0.71 |
| Triglycerides, mean, mg/dl (SD) | 139 (85) | 130 (89) | 0.005 |
| Regular Aspirin use, n (%) | 340 (35.6) | 958 (17.3) | <0.001 |
| Common carotid intimal-medial thickness, mean mm, (SD) | 0.92 (0.20) | 0.86 (0.19) | <0.001 |
| Internal carotid intimal-medial thickness, mean mm (SD) | 1.27 (0.67) | 1.04 (0.58) | <0.001 |
| Hemostatic factors | |||
| CRP**, mean mg/L | 1.70 | 1.95 | |
| ln CRP | 0.53 (1.10) | 0.67 (1.17) | 0.001 |
| D-dimer**, mean ug/ml | 0.24 | 0.22 | |
| ln D-dimer | −1.42 (0.94) | −1.51 (0.92) | 0.008 |
| Fibrinogen antigen, mean mg/dl, (SD) | 360 (75) | 344 (73) | <0.001 |
| Factor VIII, mean % (SD) | 168 (67) | 163 (67) | 0.025 |
| Homocysteine**, mean umol/L | 9.1 | 8.8 | |
| ln Homocysteine | 2.21 (0.30) | 2.18 (0.30) | <0.001 |
| von Willebrand factor, mean, %, (SD) | 141 (59) | 138 (56) | 0.60 |
| Plasminogen activator inhibitor-1**, mean ng/ml | 22 | 17 | |
| ln plasminogen activator inhibitor-1 | 3.09 (0.86) | 2.87 (0.91) | 0.02 |
**
Geometric means
ln=natural log