Table 2.

Adjusted mean hemostatic factor levels by statin use, MESA, 2000–2002

Factor	Statin users	Nonusers	% Difference (95% CI)	P value
D-dimer*,ug/ml
Model 1†	0.21	0.22	−5.7 (0.0, −11.1)	0.05
Model 2	0.21	0.23	−9.0 (−3.3, −14.4)	0.002
Model 3	0.20	0.22	−9.2 (−3.4, −14.8)	0.003
Model 4	0.20	0.23	−7.4 (−1.7, −12.8)	0.01
Fibrinogen, mg/dl
Model 1	356	345	3.4 (2.0, 4.8)	<0.0001
Model 2	353	345	2.3 (0.9, 3.7)	0.002
Model 3	356	344	3.4 (1.9, 4.8)	<0.0001
Model 4	356	345	3.4 (2.1, 4.7)	<0.0001
Factor VIII, %
Model 1	164	163	0.2 (−2.6, 2.9)	0.90
Model 2	159	164	−3.0 (−5.9, −0.2)	0.04
Model 3	158	164	−3.5 (−6.4, −0.6)	0.02
Model 4	160	164	−2.5 (−5.3, 0.3)	0.08
Homocysteine*, umol/L
Model 1	8.79	8.85	−0.6 (−2.5, 1.3)	0.54
Model 2	8.76	8.87	−1.2 (−3.2, 0.7)	0.22
Model 3	8.73	8.87	−1.5 (−3.5, 0.5)	0.14
Model 4	8.76	8.87	−1.2 (−3.1, 0.8)	0.24
CRP*, mg/L
Model 1	1.67	1.94	−14.3 (−7.5, −20.6)	<0.0001
Model 2	1.55	1.97	−21.1 (−15.2, −26.7)	<0.0001
Model 3	1.54	1.96	−21.2 (−15.1, −26.9)	<0.0001
vWF, %
Model 1	138	141	−1.7 (−9.2, 5.8)	0.66
Model 2	136	141	−3.5 (−11.3, 4.4)	0.39
Model 3	134	140	−4.3 (−12.4, 3.8)	0.29
PAI-1*, mg/ml
Model 1	22.9	17.9	28.1 (7.0, 53.4)	0.007
Model 2	21.9	18.0	21.7 (2.7, 44.3)	0.02
Model 3	21.4	17.7	20.7 (2.6, 42.0)	0.02
Model 4	21.8	18.0	21.1 (2.0, 43.8)	0.03

^*Geometric means reported

^†Model 1 = adjusted for age, sex, education, individual income, race

Model 2 = model 1 + adjustment for smoking status, current alcohol use, BMI, diabetes status, HTN status, ASA, and sex/HRT use among women (in lieu of a dichotomous sex variable)

Model 3 = model 2 + LDL, triglycerides, insulin, carotid intimal-medial thickness z-score

Model 4 = Model 2 + CRP