Figure 6. T cell-intrinsic p38α activity is dispensable for Th1 or iTreg differentiation.

(A) Expression of Foxp3⁺ in WT and p38α^ΔT naïve T cells activated with CD103⁺ and CD103^– MLN DCs, in the presence of αCD3(0.5 μg/ml), for 5 days. (B) Expression of Foxp3 in WT and p38α^ΔT naïve T cells differentiated under iTreg conditions for 5 days. (C) Expression of IFN-γ in WT and p38α^ΔT naïve T cells differentiated under Th1 conditions for 5 days, followed by PMA and ionomycin stimulation and intracellular staining. Data are representative of 2 (n=4 mice per group) independent experiments.