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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Ophthalmology. 2013 Apr 16;120(7):1324–1336. doi: 10.1016/j.ophtha.2012.12.044

Figure 1. Facial lentigines and ocular abnormalities in Xeroderma pigmentosum (XP) patients of different ethnicities.

Figure 1

A) Case 1 is 5-year old African American XP-C patient (XP444BE) with lentigines on her skin. B) Case 2 is 13-year old First Nations XP-C patient (XP83BE) with many lentigines, ocular surface injection, and sunburn. C) Case 3 is 39-year old Hispanic XP-C patient (XP131BE). She is originally from the Dominican Republic. The patient has a history of skin cancer, but no history of eyelid or ocular surface cancer. Many prominent lentigines are seen on her face and neck. The patient was fairly darkly pigmented when younger, however now pigmentation has been lost, resulting in hypopigmented areas. D) Case 4 is 46-year old Caucasian XP-C patient (XP1BE).33–35 She underwent bilateral orbital exenteration at ages 32 and 36 due to recurring invasive squamous cell carcinoma of the ocular surfaces and basal cell carcinoma of the lids, including one squamous cell carcinoma that occurred on the palpebral conjunctiva of the upper eyelid—a non-sun-exposed area.36 This patient, originally light-skinned, has many darkly pigmented lentiginous areas on her face. She died at age 49 from uterine cancer.28,33