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Retention of mutant decorin in the ER is associated with dilated ER. HEK293T cells were transfected with either WT or mutant decorin cDNA. In agreement with our transgenic mouse model, compared with WT transfected cells (A, arrows), the 952delTDcn transfected 293 cells have widely spread dilated membrane structures (B, thick arrows). Insets: Magnification of areas indicated by arrow in A and thin arrow in B. Scale bars: 2 μm (A and B).
