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. 2013 Jul;183(1):19–25. doi: 10.1016/j.ajpath.2013.03.004

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© 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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H&E-stained sagittal sections of the distal femoral epiphysis, physis, and metaphysis in control (A, C, and E) and ON (B, D, and F) mice. Location of vessels supplying the epiphysis is indicated in A and B by an arrow. A: Normal marrow and trabecular bone. B: Steroid-induced severe ON, diffusely necrotic epiphyseal marrow, and trabecular bone. C: Magnification of boxed area in A shows healthy osteocytes within lacunae and normal hematopoietic cells. D: Magnification of boxed area in B shows loss of osteocytes within lacunae and necrotic bone marrow. E: Normal transcortical arteriole. F: Degeneration, necrosis, and luminal occlusion of transcortical arteriole in mouse with ON. Original magnification: ×40 (A and B); ×400 (C and D); ×600 (E and F).